ICD-10-CM · Chapter 4 · E00-E89
E88 Other and unspecified metabolic disorders
Excludes 1 (cannot be coded together)
- histiocytosis X (chronic) (C96.6)
Use Additional Code
- codes for associated conditions
Subcodes
Each subcode links to a detail page with full clinical annotations.
| Code | Description | Billable |
|---|---|---|
| E88..0 | Disorders of plasma-protein metabolism, not elsewhere classified | No |
| E88..01 | Alpha-1-antitrypsin deficiency | Yes |
| E88..02 | Plasminogen deficiency | Yes |
| E88..09 | Other disorders of plasma-protein metabolism, not elsewhere classified | Yes |
| E88..1 | Lipodystrophy, not elsewhere classified | No |
| E88..10 | Lipodystrophy, unspecified | Yes |
| E88..11 | Partial lipodystrophy | Yes |
| E88..12 | Generalized lipodystrophy | Yes |
| E88..13 | Localized lipodystrophy | Yes |
| E88..14 | HIV-associated lipodystrophy | Yes |
| E88..19 | Other lipodystrophy, not elsewhere classified | Yes |
| E88..2 | Lipomatosis, not elsewhere classified | Yes |
| E88..3 | Tumor lysis syndrome | Yes |
| E88..4 | Mitochondrial metabolism disorders | No |
| E88..40 | Mitochondrial metabolism disorder, unspecified | Yes |
| E88..41 | MELAS syndrome | Yes |
| E88..42 | MERRF syndrome | Yes |
| E88..43 | Disorders of mitochondrial tRNA synthetases | Yes |
| E88..49 | Other mitochondrial metabolism disorders | Yes |
| E88..8 | Other specified metabolic disorders | No |
| E88..81 | Metabolic syndrome and other insulin resistance | No |
| E88..810 | Metabolic syndrome | Yes |
| E88..811 | Insulin resistance syndrome, Type A | Yes |
| E88..818 | Other insulin resistance | Yes |
| E88..819 | Insulin resistance, unspecified | Yes |
| E88..82 | Obesity due to disruption of MC4R pathway | Yes |
| E88..89 | Other specified metabolic disorders | Yes |
| E88..9 | Metabolic disorder, unspecified | Yes |
| E88..A | Wasting disease (syndrome) due to underlying condition | Yes |
Plain-language term for this code
The following entry in the US Medical Glossary corresponds to ICD-10-CM category E88:
- Metabolic Syndrome — Síndrome metabólico
Last reviewed: September 2026