ICD-10-CM · Chapter 18 · R00-R99
R65 Symptoms and signs specifically associated with systemic inflammation and infection
Subcodes
Subcodes are listed below for reference. Detail pages are not available for chapters 11–22.
| Code | Description | Billable |
|---|---|---|
| R65..1 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin | No |
| R65..10 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction | Yes |
| R65..11 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction | Yes |
| R65..2 | Severe sepsis | No |
| R65..20 | Severe sepsis without septic shock | Yes |
| R65..21 | Severe sepsis with septic shock | Yes |
Last reviewed: September 2026