C21 Malignant neoplasm of anus and anal canal

Category / Non-billable header 4 subcodes

Block: Malignant neoplasms of digestive organs (C15-C26)

Excludes 2 (not included here)

  • malignant carcinoid tumors of the colon (C7A.02-)
  • malignant melanoma of anal margin (C43.51)
  • malignant melanoma of anal skin (C43.51)
  • malignant melanoma of perianal skin (C43.51)
  • other and unspecified malignant neoplasm of anal margin (C44.500, C44.510, C44.520, C44.590)
  • other and unspecified malignant neoplasm of anal skin (C44.500, C44.510, C44.520, C44.590)
  • other and unspecified malignant neoplasm of perianal skin (C44.500, C44.510, C44.520, C44.590)

Subcodes

Each subcode links to a detail page with full clinical annotations.

Code Description Billable
C21..0 Malignant neoplasm of anus, unspecified Yes
C21..1 Malignant neoplasm of anal canal Yes
C21..2 Malignant neoplasm of cloacogenic zone Yes
C21..8 Malignant neoplasm of overlapping sites of rectum, anus and anal canal Yes

Last reviewed: September 2026