Z17 Estrogen, and other hormones and factors receptor status

Category / Non-billable header 15 subcodes

Block: Estrogen, and other hormones and factors receptor status (Z17)

Notes

  • Use one code, as available, for each receptor: Z17.0, Z17.1, Z17.2-, Z17.3-

Code First

  • malignant neoplasm, such as:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of ovary (C56.-)

Subcodes

Subcodes are listed below for reference. Detail pages are not available for chapters 11–22.

Code Description Billable
Z17..0 Estrogen receptor positive status [ER+] Yes
Z17..1 Estrogen receptor negative status [ER-] Yes
Z17..2 Progesterone receptor status No
Z17..21 Progesterone receptor positive status Yes
Z17..22 Progesterone receptor negative status Yes
Z17..3 Human epidermal growth factor 2 receptor No
Z17..31 Human epidermal growth factor receptor 2 positive status Yes
Z17..32 Human epidermal growth factor receptor 2 negative status Yes
Z17..4 Combined receptor status No
Z17..41 Hormone receptor positive No
Z17..410 Hormone receptor positive with human epidermal growth factor receptor 2 positive status Yes
Z17..411 Hormone receptor positive with human epidermal growth factor receptor 2 negative status Yes
Z17..42 Hormone receptor negative No
Z17..420 Hormone receptor negative with human epidermal growth factor receptor 2 positive status Yes
Z17..421 Hormone receptor negative with human epidermal growth factor receptor 2 negative status Yes

Last reviewed: September 2026