ICD-10-CM · Chapter 3 · D50-D89
D89 Other disorders involving the immune mechanism, not elsewhere classified
Excludes 1 (cannot be coded together)
- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes 2 (not included here)
- transplant failure and rejection (T86.-)
Subcodes
Each subcode links to a detail page with full clinical annotations.
| Code | Description | Billable |
|---|---|---|
| D89..0 | Polyclonal hypergammaglobulinemia | Yes |
| D89..1 | Cryoglobulinemia | Yes |
| D89..2 | Hypergammaglobulinemia, unspecified | Yes |
| D89..3 | Immune reconstitution syndrome | Yes |
| D89..4 | Mast cell activation syndrome and related disorders | No |
| D89..40 | Mast cell activation, unspecified | Yes |
| D89..41 | Monoclonal mast cell activation syndrome | Yes |
| D89..42 | Idiopathic mast cell activation syndrome | Yes |
| D89..43 | Secondary mast cell activation | Yes |
| D89..44 | Hereditary alpha tryptasemia | Yes |
| D89..49 | Other mast cell activation disorder | Yes |
| D89..8 | Other specified disorders involving the immune mechanism, not elsewhere classified | No |
| D89..81 | Graft-versus-host disease | No |
| D89..810 | Acute graft-versus-host disease | Yes |
| D89..811 | Chronic graft-versus-host disease | Yes |
| D89..812 | Acute on chronic graft-versus-host disease | Yes |
| D89..813 | Graft-versus-host disease, unspecified | Yes |
| D89..82 | Autoimmune lymphoproliferative syndrome [ALPS] | Yes |
| D89..83 | Cytokine release syndrome | No |
| D89..831 | Cytokine release syndrome, grade 1 | Yes |
| D89..832 | Cytokine release syndrome, grade 2 | Yes |
| D89..833 | Cytokine release syndrome, grade 3 | Yes |
| D89..834 | Cytokine release syndrome, grade 4 | Yes |
| D89..835 | Cytokine release syndrome, grade 5 | Yes |
| D89..839 | Cytokine release syndrome, grade unspecified | Yes |
| D89..84 | IgG4-related disease | Yes |
| D89..89 | Other specified disorders involving the immune mechanism, not elsewhere classified | Yes |
| D89..9 | Disorder involving the immune mechanism, unspecified | Yes |
Last reviewed: September 2026