ICD-10-CM · Chapter 3 · D50-D89
D81 Combined immunodeficiencies
Excludes 1 (cannot be coded together)
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Subcodes
Each subcode links to a detail page with full clinical annotations.
| Code | Description | Billable |
|---|---|---|
| D81..0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis | Yes |
| D81..1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers | Yes |
| D81..2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers | Yes |
| D81..3 | Adenosine deaminase [ADA] deficiency | No |
| D81..30 | Adenosine deaminase deficiency, unspecified | Yes |
| D81..31 | Severe combined immunodeficiency due to adenosine deaminase deficiency | Yes |
| D81..32 | Adenosine deaminase 2 deficiency | Yes |
| D81..39 | Other adenosine deaminase deficiency | Yes |
| D81..4 | Nezelof's syndrome | Yes |
| D81..5 | Purine nucleoside phosphorylase [PNP] deficiency | Yes |
| D81..6 | Major histocompatibility complex class I deficiency | Yes |
| D81..7 | Major histocompatibility complex class II deficiency | Yes |
| D81..8 | Other combined immunodeficiencies | No |
| D81..81 | Biotin-dependent carboxylase deficiency | No |
| D81..810 | Biotinidase deficiency | Yes |
| D81..818 | Other biotin-dependent carboxylase deficiency | Yes |
| D81..819 | Biotin-dependent carboxylase deficiency, unspecified | Yes |
| D81..82 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] | Yes |
| D81..89 | Other combined immunodeficiencies | Yes |
| D81..9 | Combined immunodeficiency, unspecified | Yes |
Last reviewed: September 2026